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KMID : 0359020110440010033
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Korean Journal of Gastrointestinal Endoscopy
2011 Volume.44 No. 1 p.33 ~ p.37
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Dual Therapy Trial Using Esomeprazole and Amoxicillin as Third-line Rescue Therapy for Helicobacter pylori Infection
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Park Hyun-Kyung
Lee Dong-Ho
Suh Seung-Chul
Seo Pyoung-Ju
Kim Na-Young
Jeong Sook-Hyang
Kim Jin-Wook
Hwang Jin-Hyeok
Park Young-Soo
Lee Sang-Hyub
Shin Cheol-Min
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Abstract
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Background/Aims: The purpose of this study was to evaluate the efficacy and tolerability of dual therapy consisting of esomeprazole and amoxicillin as a rescue therapy for Helicobacter pylori infection.
Methods: From December 2009 to August 2010, 21 patients who experienced two consecutive eradication failures were included. They received esomeprazole (40 mg, b.i.d.) and amoxicillin (1,000 mg, b.i.d.) for 14 days as a third eradication regimen. Compliance and side effects were determined from an interview. H. pylori status was evaluated using the 13C urea breath test at least 6 weeks after treatment.
Results: The mean age of the patients was 59 years and included 52% males. Indications for treatment were functional dyspepsia (61.9%), peptic ulcer disease (28.6%), and gastric adenoma (9.5%). H. pylori was eradicated in 14 of 21 (66.7%) patients. Minor side effects were reported in three of the 21 patients (14.3%). These side effects consisted mainly of nausea and epigastric discomfort.
Conclusions: A 2-week course of dual therapy failed to show satisfactory results in third-line H. pylori eradication, but it was very safe and tolerable. Therefore, dual therapy constitutes an encouraging empirical strategy for the elderly and infirm patients with multiple previous eradication failures.
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KEYWORD
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Helicobacter pylori, Therapy, Proton pump inhibitor, Amoxicillin
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